TOPAMAX

Topamax (Topiramate)

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Topamax is a drug that consists of Topiramate compound, it is an anticonvulsant or an antiepileptic drug. Topamax (Topiramate) is basically used for the treatment of Epilepsy, which is caused due to some electric disturbances in the brain. Topamax (Topiramate) is manufactured by Janssen-Cilag.

What should Topamax (Topiramate) be used for?
Topamax (Topiramate) is commonly used for the treatment of Epilepsy. Epilepsy is described as a disturbance in the electrochemical activity of the discharging cells of the brain produced by a variety of neurological disorders.

In Epilepsy the problem occurs in the central nervous system, specifically the brain. As everyone knows, the brain works by sending electric signals, which control our body. The brain controls each and every expression of the body. Be it thought, emotion, impression, memory, and movement, etc. The nerves act as the transmitting or communication lines from brain to other body parts and vice-versa.

This is a normal function, but the problem arises when there is an imbalance in the transmission of these signals. The body loses control at that time and the person may perform any kind of action that is unwanted and uncontrollable. This is termed as seizure or a fit. Seizures may be of different kinds, and depending upon the kind depends on the medicine that may be prescribed. Seizures are basically characterized into two types i.e. primary generalized seizures and partial seizures. These two differ in only one point, and that is the point of origin of the seizure. This means that the area of brain from where it has started characterizes the kind of seizure.

Primary generalized seizures: In these types of seizures, both parts of brain are involved collectively. Hereditary factors are important in many of these seizures.

Partial seizures: This is limited to only one part of the brain and the problem in signals starts from a particular area of brain. Some are related to head injury, brain infection, stroke, or tumor, but in most cases the cause is unknown.

This problem may occur to any person belonging to any race, any sex, any age, etc. But, it is most commonly seen in males. And generally the problem arises at the child hood age itself.

There are number of medicines available for the treatment of Epilepsy, and Topamax (Topiramate) is one of them. However, whether it can be cured or not can only be identified by a neurologist. If the problem has worsened, then the chances of its getting cured are very less. But, if identified at a proper stage, the frequency of seizures can definitely be reduced.

How does Topamax (Topiramate) work?
Topamax (Topiramate) works by increasing the amount of the brain chemical called GABA. It has been found out that the epileptic seizures are a result of low levels of this chemical in the brain. By increasing the amount of GABA, Topamax (Topiramate) helps in the reduction of the chances of an epileptic seizure. Topamax (Topiramate) is an irreversible inhibitor of gamma- aminobutyric acid transaminase (GABA-T), the enzyme responsible for the catabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain. The mechanism of action of Topamax (Topiramate) is attributed to irreversible enzyme inhibition of GABA-T, and consequent increased levels of the inhibitory neurotransmitter, GABA. The duration of effect of Topamax (Topiramate) is dependent on the rate of GABA-T re-synthesis rather than on the plasma concentration of Topiramate.

The mechanism action of Topamax (Topiramate) is attributed to irreversible enzyme inhibition of GABA-T, and consequent increased levels of the inhibitory neurotransmitter, GABA. The duration effect of Topamax (Topiramate) is dependent on the rate of GABA-T re-synthesis rather than on the plasma concentration of Topiramate.

A prescription is required to get Topamax (Topiramate)!
Topamax (Topiramate) should not be used without the consent of a doctor. Since the problem of epilepsy is a very serious and major problem, only a doctor can identify the suitability of a particular drug for an individual on the basis of the intensity and type of seizure. As such, Topamax (Topiramate) has been found very useful in Epilepsy, but it is strictly advisable to consult a doctor specializing in this field.

In what dosage amount should Topamax (Topiramate) be taken?
At the start it is recommended to take 50mg of Topamax once a day, and the dosage of Topamax (Topiramate) may be increased up to 200mg in adults depending upon a person’s need. The dose in children is based on body weight and will be determined by the doctor. However, the dosage depends from individual to individual and can be identified by a medical practitioner of this field.

For what time duration should Topamax (Topiramate) be taken?
As per the research done on this up till now, there is no specific time period identified for the duration of Topamax use. The duration of Topamax intake may vary from individual to individual, depending upon the mental health. The intake of Topamax (Topiramate) should not be stopped without the advice of a medical practitioner.

Precautions to be taken while using Topamax (Topiramate)!

  1. If a person has a family history of some disorder of brain, the doctor must be informed of the same, before the intake of Topamax (Topiramate).
  2. Topamax (Topiramate) may cause problems to a female who is pregnant or is breast feeding.
  3. If a person has an allergy with Topamax (Topiramate) or any specific drug.
  4. If a person has or has had a liver problem, Topamax (Topiramate) may not be advisable.
  5. Persons with Diabetes must take Topamax (Topiramate) under doctor’s guidance.
  6. Topamax (Topiramate) is not recommended for seizures due to hypoglycemic or other metabolic causes. Appropriate diagnostic procedures should be performed.
  7. Topamax (Topiramate) may not be advisable if a person has to undergo a surgery.
  8. If a person is taking Topamax, or any other drug, alcoholic beverages should not be taken without the consent of a doctor.

What side effects does Topamax (Topiramate) have?

  1. Damage to retina
  2. Rashes on the skin
  3. Confused state of mind
  4. Lack of concentration
  5. Problem with speech
  6. Blood problems
  7. Restlessness
  8. Swelling
  9. Pain
  10. Change in sleeping pattern

Note: The intensity of the above may vary from person to person.

Storage conditions for Topamax (Topiramate)!
Topamax (Topiramate) should be stored at room temperature and the place where it is kept should not have excessive moisture and temperature. However, Topamax (Topiramate) should be kept in the container it came in, tightly closed, and out of reach of children. Also, as per the general indications for any medicine, Topamax should also be thrown away if it is outdated.

Where to buy Topamax (Topiramate) from?
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Why Topamax (Topiramate) from Canada?
Online Canadian Pharmacy gives you Topamax (Topiramate) at very cheap rates. The reason behind this is the regulation of prices by the Canadian government and also because of the favorable exchange rate. Since, the Canadian dollar is cheaper as compared to the US Dollars, so one can buy more Topamax from Canada, thereby saving a lot of money.

Major Drug (Topamax and other Anticonvulsant or Antiepileptic) Manufacturers

  • Roche
  • Pharmacia
  • Pfizer
  • Sanofi-Synthelabo
  • Hoechst Marion Roussel
  • GlaxoSmithKline
  • AstraZeneca
  • Parke-Davis
  • Novartis
  • Celltech
  • Janssen-Cilag

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